- Title
- In-vivo (Albino Mice) and in-vitro Assimilation and Toxicity of Zinc Oxide Nanoparticles in Food Materials
- Creator
- Bashir, Saiqa; Awan, Muhammad Siddique; Farrukh, Muhammad Akhyar; Naidu, Ravi; Khan, Shahzad Akbar; Rafique, Nagina; Ali, Shaista; Hayat, Imran; Hussain, Imtiaz; Khan, Muhammad Zubair
- Relation
- International Journal of Nanomedicine Vol. 17, p. 4073-4085
- Publisher Link
- http://dx.doi.org/10.2147/ijn.s372343
- Publisher
- Dove Medical Press
- Resource Type
- journal article
- Date
- 2022
- Description
- Purpose: Recent advances in nanotechnology have given rise to the potential utilization of nanoparticles as food, nano-medicine/biomedicines. Patient: The study aimed to investigate the effects of nano-zinc oxide (nano-zinc) on the bio-assimilation of mineral (Zn) in mice, aged 3– 6 weeks. Methods: ZnO nanoparticles were added to the basal diet as a supplement at amounts of 0.07, 0.14 and 0.21 mg/kg. The synthesized material was characterized by Fourier transform infrared spectrophotometer, particle size, scanning electron microscope, Thermogravimetric Analysis Thermal, X-ray diffraction spectrophotometer and Zeta potential. Results: In-vitro bioavailability of synthesized group ZnO (120 nm) was 43%, whereas for standard group ZnO (50 nm) was reported as 55%. In-vivo bioavailability of zinc oxide illustrated the maximum absorption level compared with the control. In-vivo toxicity was characterized as damage done to the liver and spleen tissues with a high dose of 0.21 mg/kg, while smaller doses indicated no toxic effects. Conclusion: The study provided important insights on the toxicological effects of ZnO nanoparticles, depending on dose rate and bio-assimilation, as well as particles, under various conditions (in-vitro and in-vivo). These findings will motivate further detailed research on nano-based medicine for alleviating malnutrition conditions.
- Subject
- bioavailability; toxicity; nanoparticles; nanomedicine; food
- Identifier
- http://hdl.handle.net/1959.13/1489259
- Identifier
- uon:52664
- Identifier
- ISSN:1176-9114
- Language
- eng
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